Regulatory and Exhausted T Cell Responses to AAV Capsid
نویسندگان
چکیده
منابع مشابه
Regulatory and Exhausted T Cell Responses to AAV Capsid.
Recombinant adeno-associated viruses (AAVs) are quickly becoming the preferred viral vector for viral gene delivery for the treatment of a wide variety of genetic disorders. However, since their use in a clinical trial targeting hemophilia B patients 10 years ago, immune responses to the AAV capsid appear to have hampered some of the early clinical gene transfer efficacy. Indeed, AAV-based gene...
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Adeno-associated virus (AAV) has become one of the most promising vectors in gene transfer in the last 10 years with successful translation to clinical trials in humans and even market approval for a first gene therapy product in Europe. Administration to humans, however, revealed that adaptive immune responses against the vector capsid can present an obstacle to sustained transgene expression ...
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ژورنال
عنوان ژورنال: Human Gene Therapy
سال: 2017
ISSN: 1043-0342,1557-7422
DOI: 10.1089/hum.2017.022